The Self-Experiment: Testing a Supplement Properly on Yourself
Placebo, regression to the mean and misremembered adherence guarantee you will feel better whether or not it works. The n-of-1 method that separates the two, in five rules.
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12 articles
Placebo, regression to the mean and misremembered adherence guarantee you will feel better whether or not it works. The n-of-1 method that separates the two, in five rules.
Andrew Huberman named his 5 daily supplements on Diary of a CEO, then described a free habit he says matters more. We checked each claim against the primary research: two hold up cleanly, two need real caveats, one is shakier than it sounded, and the free habit is the best-supported claim in the episode.
A supplement refills an empty tank. It does not enlarge a full one. The shortlist that survives that rule, the trials behind each one, and why iron is different for men.
A 12-point sperm optimisation list is doing the rounds on Instagram. Two items have randomised trial support at a named dose. Several rest on rat data. One is anatomically wrong. Here is each one graded.
Glutathione is the body's master antioxidant, but most oral supplements fail. Learn how NAC solves the bioavailability problem, clinical evidence for both, dosing guidelines, and practical stacking advice.
Most melatonin supplements contain 10 to 30 times the dose research supports. Learn why 0.3 to 0.5mg often works better than 5 to 10mg, how timing matters more than dose, and practical protocols for sleep and jet lag.
KSM-66 and Sensoril are standardized ashwagandha extracts with different plant parts, withanolide concentrations, and clinical evidence. Here is what the research shows for stress, sleep, cortisol, and strength, plus dosing, cycling, and who should avoid it.
What biotin actually does, who is truly deficient, what the evidence says about hair and nail supplementation, the lab test interference problem, and reasonable dosing.
Vitamin C does far more than support immunity. Learn about its roles in collagen synthesis, iron absorption, antioxidant recycling, and why megadosing does not help.
Genetics, sex, age, and cycle timing all influence how your body processes supplements. Here's why personalisation isn't optional. It's the point.
EPA and DHA do different things. Learn how to read an omega-3 label, when ratio matters, and how to match the right EPA:DHA balance to your health goals.
Zinc and copper compete for absorption. Learn the ratio that keeps both minerals in balance, signs of imbalance, and practical dosing guidance for safe supplementation.