Phosphatidylserine
A structural fat your brain cells are built from. One of the few supplements with an FDA-recognised cognitive claim.
Phosphatidylserine is a phospholipid that forms part of the structure of every neuronal cell membrane, and it carries a qualified health claim recognised by the US FDA relating to a reduced risk of cognitive decline in older adults, one of relatively few supplements with that specific regulatory recognition. It has also been studied in athletes for blunting the cortisol spike that follows intense exercise. Soy-derived and sunflower-derived phosphatidylserine perform comparably; sunflower-derived versions exist mainly as a soy-free alternative for people avoiding that allergen.
Forms and bioavailability
Not all forms are absorbed equally. The form on your supplement label affects how much your body can actually use.
| Form | Absorption | With food | Timing | Evidence |
|---|---|---|---|---|
| phosphatidylserine (soy-derived) | Typical | With food | Either | Likely |
| phosphatidylserine (sunflower) | Typical | With food | Either | Likely |
Stack Almanac tracks your phosphatidylserine source, soy or sunflower-derived, so a soy allergy or sensitivity doesn't get missed inside a nootropic blend.
Track your Phosphatidylserine in Stack Almanac
Last reviewed: 2026-07-08. Reference values are adult-general RDAs. Individual needs may vary. This page is for informational purposes only and is not a substitute for professional medical advice.