Condition protocol
An energy stack aimed at mitochondria, not another caffeine pill
Methylated B-complex, ubiquinol CoQ10, rhodiola rosea, and creatine target the actual energy-production pathway. On a statin? CoQ10 gets upgraded from optional to essential automatically.
Persistent fatigue is one of the most commonly mis-supplemented complaints there is, because the reflexive answer is caffeine or a multivitamin, neither of which touches mitochondrial energy production. Stack Almanac's Energy / Fatigue protocol targets the actual pathway: methylated B-complex and ubiquinol CoQ10 as cofactors for the electron transport chain, rhodiola rosea for perceived-fatigue reduction across multiple RCTs, and creatine monohydrate for ATP regeneration.
Iron sits as optional, and deliberately so: it's genuinely effective for fatigue when ferritin is confirmed low, and genuinely harmful when supplemented without deficiency. The protocol gates it behind a test, same as the ADHD and energy overlap in the underlying evidence.
The protocol's own disclaimer is direct: persistent fatigue can signal thyroid issues, anaemia, or sleep apnoea, and a GP visit for bloodwork should come before assuming a nutritional cause.
The challenges
Statins deplete CoQ10 and most people never connect the two
If you're on a statin, your CoQ10 levels are likely lower than they'd otherwise be, and low CoQ10 shows up as exactly the kind of fatigue people reach for a multivitamin to fix.
Iron gets supplemented on a hunch, not a ferritin result
Iron deficiency is a real, leading cause of fatigue. Supplementing without confirming deficiency first is also genuinely harmful. The gap between those two facts is where most fatigue stacks go wrong.
Fatigue gets treated as a supplement problem before a medical one
Thyroid dysfunction, anaemia, and sleep apnoea all present as persistent tiredness. None of them respond to a better stack. Bloodwork should come first.
B-complex quality varies and MTHFR variants make it worse
Non-methylated folic acid doesn't convert efficiently for a meaningful chunk of the population carrying common MTHFR variants. A generic B-complex can underperform for exactly the people who need it most.
How Stack Almanac helps
Four supplements targeting the actual energy pathway
Methylated B-complex (strong evidence, per-label dose), ubiquinol CoQ10 200mg (strong evidence, critical for the electron transport chain), and rhodiola rosea 400mg (moderate evidence, reduces perceived fatigue across multiple RCTs) as the essential core. Creatine monohydrate 5g sits optional but strongly evidenced.
CoQ10 upgrades to essential if you're on a statin
Statins are well-documented to deplete CoQ10. Log a statin in your bio profile and the Advisor makes CoQ10 essential rather than optional, since the depletion mechanism is specific and well understood.
Iron gated behind a ferritin test, same discipline as the ADHD protocol
Iron is marked non-essential and flagged for ferritin testing first. Supplementing without confirmed deficiency (under roughly 30 ng/mL) risks iron overload rather than fixing anything.
Matched to your bio profile automatically
Add "chronic fatigue," "CFS," "energy," or "tiredness" to your health conditions or primary concerns and this protocol surfaces in your Protocols tab as a match.
The Advisor points you to bloodwork before assuming the cause
If persistent fatigue hasn't been checked against thyroid function, anaemia, or sleep apnoea, the Advisor says so, because those conditions don't respond to a better supplement stack.
The Energy / Fatigue Protocol
Strong evidence: B-complex, CoQ10, creatine, iron (if deficient). Moderate: rhodiola. £35–55/mo estimated.
The list above is free. This is what isn't.
- CoQ10 upgrades from optional to essential automatically the moment a statin shows up in your medications.
- Iron only gets added once ferritin confirms you're actually deficient, never a blind recommendation.
- The Advisor flags when persistent fatigue looks more like a GP problem than a supplement one.
Free 7-day trial · no credit card required