Creatine forms
Monohydrate is the one with the evidence. Every other form is priced as an upgrade and has yet to earn it.
The International Society of Sports Nutrition calls creatine monohydrate the most effective ergogenic supplement available for high-intensity work and lean mass, and the most extensively studied and clinically effective form of creatine. On everything else its 2017 position stand is blunt: claims that other forms are degraded less in the body or reach muscle better are unfounded, and clinical evidence has not shown that citrate, serum, ethyl ester, buffered forms or nitrate improve creatine retention over monohydrate. A follow-up paper adds that most studies show these other forms have less physiological impact, not more. Buffered creatine has its own negative trial, which found no greater change in muscle creatine, body composition or training adaptation than monohydrate. To saturate stores, the stand describes 5g four times daily for five to seven days, then 3 to 5g a day, or 3 to 5g a day from the start reaching the same place in three to four weeks.
Stack Almanac records which creatine form is in each product you log, which is the only way to see what the premium forms in your stack have actually cost you over a year.
What this is based on
- 1.International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicineJournal of the International Society of Sports Nutrition 2017;14:18monohydrate as most effective and most studied form; claims for other forms unfounded; loading and maintenance dosing; no compelling evidence of renal harm in healthy or clinical populations
- 2.Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?Journal of the International Society of Sports Nutrition 2021;18:13no peer-reviewed papers show creatine salts or other forms raise muscle creatine more than monohydrate; most studies show less physiological impact
- 3.A buffered form of creatine does not promote greater changes in muscle creatine content, body composition, or training adaptations than creatine monohydrateJournal of the International Society of Sports Nutrition 2012;9:43the specific negative trial for buffered creatine (Kre-Alkalyn), cited as reference 60 in the 2017 position stand
See also the full reference for creatine.
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